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In rat models of PD, IN DFO has been reported to protect dopaminergic neurons in the substantia nigra and ameliorate motor deficits, suggesting IN DFO reaches the midbrain regions at pharmacologically active concentrations (Febbraro et al., 2013)

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Paracetamol (Acetaminophen) Mechanism: • Weak inhibition of prostaglandin synthesis in the CNS (central action)